Nearly 30 years ago I was first diagnosed bipolar. I'm now 73 yrs old. The first medication I was prescribed was Zoloft (sertraline), along with anti-anxiety meds--no longer being prescribed by the VA , where I get my primary health care due to location and unavailability of most of the healthcare providers I need. Anyway, sertraline worked well for about 2-3 years until I was prescribed more and different antidepressants until less than a year ago at which time the nurse practitioner I'm seeing switched me back to sertraline which helped get me out of the major depression I've been going through. I'm feeling a lot less depressed, and along with the mood stabilizer I'm on (depakote), am doing as well as possible that someone with mid-stage Parkinson's Disease can be: declining cognitive skills, tremors, body rigidity and loss of balance and coordination, insomnia, dyskinesia, and other symptoms. Then again, I'm not the same person I was when I first began taking sertraline. It may be worth a try--going back to an antidepressant that worked for you in the past. My feeling is that the med's I'm taking will eventually wear me down physically and/or mentally in the long run. They're great for Big Pharma and the investors, but as patients, most of us will suffer from long term effects of drug use. I don't take any med's for my PD and haven't noticed a difference--I'm resigned to believing I'm simply in a later stage of life; my strict diet and daily exercise routine have bought me more quality of life time (can't surf or play tennis anymore) but I use my martial arts training to play tai chi chuan at a high level, although it gets embarrassing when I start trembling or lose my balance when teaching groups of learners; but I studied under some great masters over the years and while most of my students think they're doing tai chi chuan, they're merely following me along and don't even seem to care about all the training, history, and work I put in to be able to use the internal Chinese art form as the defense techniques for which it was designed.