Donna -- I find your discovery to be fascinating and admire the way you pay close attention to what your body is doing under different conditions. Yes, we are all warned of the dangers of ibuprofen, but generally, these warnings come in a vacuum. Some of the medications we´re routinely prescribed in relation to heart health themselves carry risks (even to the heart, in some cases), and when one ventures to try an OTC product or supplement, yes, we should be sure, with physician input, to minimize risks of harming ourselves, but we should also ask our doctors whether, ON BALANCE, the product of interest could actually do more harm, across our body systems, than do the medications we may already be taking or may soon be advised to take. The challenge there is that most physicians today consider all OTCs and nutraceuticals to be worthless or worse regardless of the availability of studies and meta-analyses that may point to favorable safety margins for these products, and so I can think of no physician I have ever encountered who would ever do the kind of comparative risk analysis Iḿ advocating. Ultimately, we make our own decisions, though, and when conventional medicine is not helping, or may be hurting, there are moments when we choose to forge ahead, taking full responsibility for whatever may ensue. That is sometimes the best that we can do. And frankly, I take leaps like this quite often, keeping my PCP as closely apprised as I can.