← Return to High anxiety regarding Reclast or Prolia decison for OP meds

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@mayblin

@gently you presented a thought provoking path! Good studies for either pth analog to evenity or evenity to pth analog are almost non-existent. The serial anabolic exposure from pth analog to evenity to pth analog calls for a veteran bone specialist's attention. A bold yet innovative idea to say the least. Are there any conceptual bases to back it up? Or, do you see a clear advantage in the absence of an antiresorptive (either reclast or prolia in this case), given anny's need for a quick boost in bmd (hence a reduction of her very high frax score) in a short periods of time?

Curiously, do you think toggling between tymlos and forteo could enhance anabolic effects given their differences in receptor binding?

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Replies to "@gently you presented a thought provoking path! Good studies for either pth analog to evenity or..."

mablin,
thanks for sewing with this thread.
The advantage of the absence of bisphosphonate would be that it allows PTH to build strong bone.
I also suspect that part of the added bone density with bisphosphonates has to be a measurement of the bisphosphonate itself. That might only matter when the TBS indicates structural abnormality. Resistance to osteoporotic vertebral fracture is more dependant upon the trabecular bone than the cortical bone.