I developed a large kidney stone while taking Tymlos. This is a known possible side effect. I told the NP that I have a strong family history of kidney stones, but she just blew it off. When I started having pain, she denied that it could be a kidney stone because the pain was not in the location that pain from a kidney stone would usually be. During the next 9 months, I saw my gynecologist, my gastroenterologist, my PCP and a urologist. Even the urologist refused to believe it was a kidney stone. I finally ended up in the ER with severe pain. I had a very large stone - too large to ever be able to even get out of my kidney on its own. I had a surgical procedure to place a stent in my ureter. I lived with that miserable stent for a month before they performed surgery to break up the stone and remove it. After that, I had to have the stent for another 2 weeks. It was almost a year of misery.
A friend of my Mom was on Fosamax. She developed leukemia, and while undergoing chemo, her oral surgeon discovered she had jaw necrosis and needed surgery right away. She couldn't have surgery due to her leukemia and chemo. She has since passed away.
I will never take any of these drugs again. I will do what I can otherwise, but in my opinion, these drugs are poison.