I would gently push back on a couple of those points.

Safe dosing has been established for a long time. It's included in the FDA prescribing information document. There is no reason, short of interactions that would intensify ivermectin's area under the curve, for the safe dosing levels to be different from what is specified for it's primary purpose.

Drug-drug interactions are also detailed in the prescribing info document. Most are specified in terms of the enzymes that metabolize ivermectin or the other drug that's being checked against it. This type of data is also specified in the prescribing information for common PCa meds. Not everyone can read that and comprehend what they need to, so it is simple enough to ask a pharmacist or your GP. As an example, I just checked the meds I take, which is quite a few, and some other common PCa meds, and found only one moderate interaction: Enzalutamide decreases the AUC of ivermectin. So, changing it in the safe direction.

Indications? I'm going to die in several months because all my PCa therapies failed, and would like to try Ivermectin.

Contraindications? Again, see the FDA prescribing info.

I'm not taking it anytime soon as I don't need to take any other meds. I just don't think it is reasonable to throw up a bunch of red flags to patients who are otherwise out of options. I would be cautious about taking it in early stages of the disease without some level of guidance from a medical professional.