I have side affects from all I've tried. Fluoxetine,venlaxafin, wellbutrin it's just what side effect is easiest to live with. Venlaxafine is good for pain but it kills my sex drive. Well, I can live with that. I also had weight loss on Prozac that was unhealthy. Be sure to check for interactions with other drugs you are taking. The doctor or pharmacist don't necessarily tell you. Watch your sugar and caffeine. Your food intake can also affect your mood, I've found.