Oh yes!! So...I started on Tamoxifen for a month, only major side effect was being very tired. Then a month later I had lupron shot. Was sick for a week. Felt like the flu. The next month same thing. And the next month same. I knew I could live being sick like that for a week every month so I had my ovaries out and was immediately switched to an AI. The side effects from lypron shot went away. I had another side effects from the Anastrozole ( couldn't stop craying and left hand ceased up) so after 1 month I switched to Exemestane and this has been much better. Good luck to you!!