All I can say is that I visited someone I would call a gifted endocrinologist (undergrad at Harvard, that is the real test of genius, then graduate work at Johns Hopkins) and he said that a very large percent of supplements are tainted or do not contain what is claimed. He speculated that as I took so many, that was what was likely causing my liver numbers to spike. I dropped almost all of them and switched to Lactaid milk for my calcium needs. I felt better after doing that. Also, my osteo specialist prefers her patients to get calcium from food.