How do you decide whether to take part in a study group?

I'm also stage 4 in the bones, and have been on Orgovyx (Relugolix) for a few months, and Firmagon (Degarelix) for 2½ years before that. In combination with debulking surgery to the lesion on my spine, radiation to my spine and prostate, and Erleada (Apalutamide), they brought my PSA down rapidly from 67 to < 0.01 (undetectable) and have held it there for coming up on three years.

Everyone's cancer is different, so everyone's experience will be too. I just wanted to let you know that GnRH receptor antagonists (first Degarelix and then Relugolix) have worked well at controlling my own bone metastatic PCa.

Good luck with your decision.

From what I've read and heard (I'm not a medical person) it is a very good move. At Mayo I was told that Relugolix was proving more effective other antiandrogens. There may be other reasons why you were started on (bicalutamide) Casodex, but I'm given to understand that it is the least effective of the antiandrogens and is seldom prescribed alone. The side effects are presented as being less severe with Relugolix (Orgovyx).
If you are not on a bisphosphonate, you might ask about Zometa (zoledronate).
wishing you the best luck

Being in stage 4 and having gone through a substantial clinical trial that worked like nothing had prior, here's my opinion. If, what you have done or are doing hasn't resolved the problem, move on. Cancer doesn't wait for anyone for any reason.

Ask about risks, is this a double blind with some getting medication and some not or is it examining 2 different drugs and outcomes.
Once you have sufficient information you can make a reasoned decision