Thank you for this information. I have been taking ALA for a year and it helped so much with my localized neuropathy in the toes. I, too, read that acetyl-l-carnitine was proving extremely successful in trials. However, the third day of taking that supplement is when my neuropathy morphed into burning, pins and needles from my knees down to my feet. It could be a coincidence but the symptoms started one hour after ingesting it the third day. Has anyone heard of having a reaction like this to a carnitine supplement?