← Return to High anxiety regarding Reclast or Prolia decison for OP meds

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@mayblin

From one evenity study I read, on average, bmd increased a little over 4% during 0-3mo, closer to 4% during 4-6mo, then roughly 3-4% during months 7-12. If therapy continues, the second year had another few percentage increase in bmd so not very effective. Like you noted, efficacy in bone building is greatest during first few months.

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Replies to "From one evenity study I read, on average, bmd increased a little over 4% during 0-3mo,..."

@mayblin I made myself crazy wondering if I should stop Evenity after 3 months or 4 month or 6 months and so on as the bone building supposedly decreases. I did not stop, I've had 10 so far. I think the question is does it decrease so much that there's no point in continuing to take it. I even saw in another forum that a nurse had advised someone to stop as there was no point in continuing.
I think we have all gotten confused over this. Assuming your numbers are correct (and I saw that study to) the rate of increase in bone density after 6 months is about a half of what it was in the first six months. But it's still a nice gain in months 7-12. 3-4% for 6 months means that the yearly rate would be 6-8% which is getting close to Forteo treatment yearly increases isn't it? Nothing to sneeze at or dismiss because of the statement that most bone building occurs in the first several months.

Maybe it's the P1NP that spikes quickly and then returns to normal that has everyone thinking it can't be building bone because the P1NP is no longer elevated. Maybe that means that it's functioning as an anti-resorptive and not building new bone but maybe we just don't understand it well enough. Maybe after that P1NP spike it keeps building bone despite the P1NP dropping back down quickly. Seems to me the important point is that the increase in bone density continues quite nicely. I go with the DXA scores on this one. The 13% gains they got for one year in two large studies and the reduced fracture rates. I'm getting a DXA this coming week. Fingers crossed.