Yes, on one hand--when my gall bladder had to be removed--they couldn't do it via laser but had to do it the "old fashioned" way due to adhesions but with 2 surgeries the food and poop went right through me due to the dumping syndrome with the first one and then malabsorption with the second so food was going through faster and I wasn't getting any calories. Now with the suppositories I haven't been nauseous after each meal like I was and have put on a few pounds -- I should do them every day--but found I need to ease into it--so it's two days on and one day off or I get heartburn. Always something!