@copingatround2 the Oncotype test is done on tumors that are ER+ and HER2- with up to 3 positive nodes. Many of us who would have had chemo before this kind of testing (Mammaprint is another one) avoided chemo as a result of a low score. I had a grade 3 cancer, highish Ki67%, lymphovascualar invasion and a positive then equivocal then negative HER2! I as headed for chemo but my Oncotype was 8. I did letrozole for 5 years after double mastectomy. No radiation or chemo. I am 10 years out knock on wood.