@windyshores i think a successful prolia withdrawal (prevention of rebound) will be fracture free as first measure, then bmd preservation. Most popular measure to prevent rebound seems reclast infusion. Some review papers showed there were some failures (as measured by fracture incidence) with the use of reclast. The McClung/Kendler paper showed dampened effects of evenity after 2 shots of prolia. I didn't read the whole publications so I'm not sure if fractures were reported in this sequence study. Even if they occurred, the small number of subjects involved may not lead to any statistical significance. I didn't dig into the evenity->reclast-->evenity sequence. Only came across one study by Japanese researchers. But they mixed reclast with other bps and I couldn't figure out a clear answer. I thought you or someone else mentioned awhile back re a clinical trial was going on for evenity to reclast to evenity sequence.