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← Return to High anxiety regarding Reclast or Prolia decison for OP meds
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High anxiety regarding Reclast or Prolia decison for OP meds
Osteoporosis & Bone Health | Last Active: Sep 22 4:39pm | Replies (165)Comment receiving replies
@mayblin so Evenity takes care of rebound after 1 year Prolia?
With the sequence Evenity-Prolia- Evenity , is Reclast used afterwards?
I am still nervous that Evenity has not been adequately researched or tried out on the market. I am satisfied about cardiovascular risks, which were well-researched and don't seem concerning despite the warning. But bone marrow inflammation and effects on B cell acquired immunity have not been well-studied, not to mention the long term effects on joints.
Basically we do best if we do anabolic first. Yup. Andy maybe it is better to take a break after Tymlos or Evenity if doing a second course, without locking in with Reclast, Fosamax or doing Prolia.
Replies to "@mayblin so Evenity takes care of rebound after 1 year Prolia? With the sequence Evenity-Prolia- Evenity..."
@windyshores i think a successful prolia withdrawal (prevention of rebound) will be fracture free as first measure, then bmd preservation. Most popular measure to prevent rebound seems reclast infusion. Some review papers showed there were some failures (as measured by fracture incidence) with the use of reclast. The McClung/Kendler paper showed dampened effects of evenity after 2 shots of prolia. I didn't read the whole publications so I'm not sure if fractures were reported in this sequence study. Even if they occurred, the small number of subjects involved may not lead to any statistical significance. I didn't dig into the evenity->reclast-->evenity sequence. Only came across one study by Japanese researchers. But they mixed reclast with other bps and I couldn't figure out a clear answer. I thought you or someone else mentioned awhile back re a clinical trial was going on for evenity to reclast to evenity sequence.
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It is my understanding that Evenity has a small amount of antiresorptive qualities. But don't quote me on that. But the big question is - is that antiresorptive enough to hold off the rebound effect from the Prolia?
I am finishing up Evenity now, 2 more injections. No issues at all.
I'm considering Reclast next.
My drug sequence has been - Forteo > Evenity, and now either Reclast or Prolia
regarding the long term effects of Evenity, I just don't know.