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High anxiety regarding Reclast or Prolia decison for OP meds
Osteoporosis & Bone Health | Last Active: Sep 22 4:39pm | Replies (165)Comment receiving replies
McClung paper: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260819/#jbm410512-bib-0014
Kendler's paper: https://link.springer.com/article/10.1007/s00198-019-05146-9 , which is reference #17 mentioned in McClung's. This is the one that details basic results in the abstract.
The studies in the papers did use evenity for 2 years for the first leg. Then they went on with either 1yr prolia or 1 yr placebo as relay, then final leg being another year of evenity. I think the key is to know if your endo indeed intends to treat you with another round of evenity. Evenity is approved for 1 year for clinical use, but second round could be done with prior authorization for medical necessity, if the doc is familiar with repeated use. Certainly your insurance can be a wild card.
If no more evenity in the near future (after 1 year of relay drug ), then your decision is a lot easier. If yes, then your reading about the relay drug (prolia vs reclast) after this round of evenity can be useful when you discussed with your endo. Do ask if s/he had used same/similar sequence or knows any clinical cases or trials/publications, and what were the outcome.
Wish you the very best!
Replies to "McClung paper: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260819/#jbm410512-bib-0014 Kendler's paper: https://link.springer.com/article/10.1007/s00198-019-05146-9 , which is reference #17 mentioned in McClung's. This is..."
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@mayblin so Evenity takes care of rebound after 1 year Prolia?
With the sequence Evenity-Prolia- Evenity , is Reclast used afterwards?
I am still nervous that Evenity has not been adequately researched or tried out on the market. I am satisfied about cardiovascular risks, which were well-researched and don't seem concerning despite the warning. But bone marrow inflammation and effects on B cell acquired immunity have not been well-studied, not to mention the long term effects on joints.
Basically we do best if we do anabolic first. Yup. Andy maybe it is better to take a break after Tymlos or Evenity if doing a second course, without locking in with Reclast, Fosamax or doing Prolia.