I was 62 when I went on HRT and am 68 now. I've been on a very low dose of .025 most of that time with no issues at all. I recently went to see Dr Felice Gersh who is an integrative gynecologis is well versed on the use of HRT and she wanted me to increase my dose to .05 for better effect. I tried it and had too much breast tenderness for my comfort so I went down to .0375 and have had no discomfort or issues on that dose.