HI JK! For me, the migraine acute meds and preventatives did not help wth severe hypnic headaches. Narcotics/sedatives did not help either, even in combinations. I did try the other recommended meds for Hypnic headaches with the exception of verapamil since I have low/normal blood pressure. I take a preventative combinaton nightly, of Indomethacin SR, Lamotrigine, and coffee/caffeine. It works very well about 85% of the time, not at all 2% of the time, and just "okay" the remaining 13% of the time (estimates!). I wonder if your daughters nocturnal headaches are migraines rather than hypnic headaches? My Migraines usually respond to Maxalt well, but I take brand Frovatriptan that takes longer to kick in, but the half life is longer (and pain relief lasts longer). I hope your daughter is doing well. I am now taking a new preventative called Emgality which is working wonders for the Migraines (thanks to my "new" MD, a Neurologist and Headache Specialist at Mayo named Dr. Whealy. I will post about it in a new post.