← Return to High anxiety regarding Reclast or Prolia decison for OP meds

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@mayblin

This paper is the study in McClung paper Fig1, line5, or reference article #17. The abstract is saying when comparing
A group: 2yr evenity --> 1 year placebo --> 1 year evenity with:
B group: 2yr evenity --> 1yr prolia -->1yr evenity

The A group second round of evenity (1yr) got bmd increase as usual (lumbar ~12%; fn and hip 5-6%) , but the B group second 1 yr evenity bmd had only 2.3% increase at lumbar and no change in hip or fn, most likely due to prolia's effect. It will be interesting to read the full paper to see what is the end results for the entire sequence A or B, because you would expect some bmd increase with prolia as a relay but lose some bmd with relay of nothing (placebo).

There was a study arm for no evenity for the first 24months, but we don't need to look at that part for your purpose.

Your TBS are not that bad, TBS 1.32 is roughly lower boundary of normal range. However, your frax score is very high. Maybe this is why your endo has another round of evenity in mind for you.

Today @awfultruth discussed dosing of reclast:
https://connect.mayoclinic.org/comment/1126775/
I wonder if you could present the paper to your endo and ask a half dose 2.5mg of reclast for 6 month and go from there, and ask endo how reclast will effect future evenity. I thought @windyshores mentioned at one point that a trial is on going for evenity -> reclast -> evenity. You never know, we might see results soon. There might be case reports that your endo knows about too.

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Replies to "This paper is the study in McClung paper Fig1, line5, or reference article #17. The abstract..."

Can you link that paper again?
Currently, Evenity is only approved for 1 year. So this paper is just a study (and wishful thinking) and not used by Dr's in the real world. Am I right in that thinking? My brain is fried trying to make a decision between the Reclast route or do the 2 doses of Prolia followed by Evenity. I'm sure I need to get this decision to my Dr asap. She has no clue I'm doubting her instructions, I don't want to be "that patient" haha. And I'll need insurance approval, so I need to make this decision asap.