I have had night time headaches for 15+ years and received a diagnosis two years ago. Since then, I have tried caffeine, Indomethacin, and Topiramate. The Topiramate worked well at first but became less and less effective with time. Additionally, it caused severe digestive problems. Now, for the good news: About four months ago, my doctor prescribed Estrogen and Progesterone for an unrelated issue. After taking these for a few days, my headaches stopped completely. I stopped the Topiramate and still had no headaches. I couldn't believe it! I quit the hormones and took the Topiramate instead and the headaches returned with a vengeance. Still not convinced, I repeated this experiment three times--same results. I have been taking the hormones for three months now and have not been awakened with a headache in that time. I am very excited!! My doctor said that these hormones are "natural" and do not have the side effects of the synthetic ones. The arrive by mail from a company called Med Quest after my doctor calls in my prescription. I sleep like a baby now and awaken feeling refreshed.