Connect
← Return to High anxiety regarding Reclast or Prolia decison for OP meds
Discussion
High anxiety regarding Reclast or Prolia decison for OP meds
Osteoporosis & Bone Health | Last Active: Sep 22 4:39pm | Replies (165)Comment receiving replies
I'm in a tough spot but maybe I'm making it tougher than I should. The easiest decision would be Reclast next, then with my Dr figure out the next drug. I'm so tired of doing nothing but reading about this. One study always leads to another... If I chose Reclast as my next treatment drug this October, is that usually given for 3 years straight? I'm worried about the side effects and can I make it thru 3 infusions.
I can't figure out what this study is reporting, it seems vague or else just not stating their conclusion.
https://link.springer.com/article/10.1007/s00198-019-05146-9
Replies to "I'm in a tough spot but maybe I'm making it tougher than I should. The easiest..."
@255anny, thanks!
Connect
This paper is the study in McClung paper Fig1, line5, or reference article #17. The abstract is saying when comparing
A group: 2yr evenity --> 1 year placebo --> 1 year evenity with:
B group: 2yr evenity --> 1yr prolia -->1yr evenity
The A group second round of evenity (1yr) got bmd increase as usual (lumbar ~12%; fn and hip 5-6%) , but the B group second 1 yr evenity bmd had only 2.3% increase at lumbar and no change in hip or fn, most likely due to prolia's effect. It will be interesting to read the full paper to see what is the end results for the entire sequence A or B, because you would expect some bmd increase with prolia as a relay but lose some bmd with relay of nothing (placebo).
There was a study arm for no evenity for the first 24months, but we don't need to look at that part for your purpose.
Your TBS are not that bad, TBS 1.32 is roughly lower boundary of normal range. However, your frax score is very high. Maybe this is why your endo has another round of evenity in mind for you.
Today @awfultruth discussed dosing of reclast:
https://connect.mayoclinic.org/comment/1126775/
I wonder if you could present the paper to your endo and ask a half dose 2.5mg of reclast for 6 month and go from there, and ask endo how reclast will effect future evenity. I thought @windyshores mentioned at one point that a trial is on going for evenity -> reclast -> evenity. You never know, we might see results soon. There might be case reports that your endo knows about too.