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Bone turnover markers (CTX and P1NP): do you have a baseline?

Osteoporosis & Bone Health | Last Active: Oct 5 5:35pm | Replies (183)
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@magwil01

I have had osteoporosis for 8 years and have tried many drugs with 3 different doctors. My previous endocrinologist gave me Fosamax which caused jaw necrosis (I had taken for 2 years and needed dental work) and when that was discovered, she sent me to a specialist that deals only with osteoporosis. No one has ever given me a test for ctx or p1np and this is the first I have heard of that. I have been on forteo for 5 years now (yes, more than anyone else I suppose but I can't take the other drugs). Should I have been given a ctx or p1np ever? Do these test possibly have other names that I would recognize? Sounds like it is to late to get a base line.

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Replies to "I have had osteoporosis for 8 years and have tried many drugs with 3 different doctors...."
mayblin | @mayblin | Aug 19 5:12pm

Hi @magwil01 you are the first case that I've heard of getting Forteo for 5 years. Was is a continous 5 year treatment? Yes you missed baseline testing of bone markers. But the most important thing is Forteo helped you recover from jaw necrosis. If it is the only drug you could take, then testing bone markers from this point on may not be necessary because what can you or your doctor do without Forteo? Forteo is known to have a finite 'anabolic window'. Likely after 2 years it has much less effect in building more bones or increasing bone density. However, it may maintain bone mass if you stay on it; it is just very expensive.

P1NP: Procollagen Type 1 Intact N Terminal Propeptide
CTX: Collagen Type 1 C Telopeptide, or C Telopeptide

If you could, do you mind sharing your dexa results (in bmd% increase or T score) during the years that you are on Forteo? Or if you prefer, could you private message me please? I'm very interested in results from continuous Forteo therapy beyond 2 years as I'm at the end of 2-year Forteo. Thanks you very much!

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