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High anxiety regarding Reclast or Prolia decison for OP meds
Osteoporosis & Bone Health | Last Active: Sep 22 4:39pm | Replies (165)Comment receiving replies
@mayblin
@windyshores
That is very interesting. Thank you for the link to that study. I do recognize 2 of the author's names 🙂 So, the treatment sequence my Dr is suggesting is not exactly new or unheard of. My concerns would be, 1). Would the second course of Evenity be enough to hold off the rebounding effect from the Prolia? 2) The very small number of participants in this study.
3) The fact that the increases in BMD were smaller than the initial increases that one gets from the first course of Evenity. 4). After the 2nd course of Evenity, would that be followed by Zolendronate?
I feel somewhat better about this sequence, but doing this kinda makes me feel like I'm doing my own drug study! I wish there was more written about this sequence. The safety aspect appeared ok in the study, so that might be of no high concern. My biggest concern is the rebounding from Prolia. But since the Prolia would be 1 year (2 doses) is the rebounding a risk after just 2 doses? I have read that it can happen after just one dose. Obviously, I have to make a decision. The lack of information about the sequence has me concerned. Of course, I could talk to my Dr but I'd like to be better informed before I do that, so that means I will dig further. Oh gosh, more sleepless nights.
@windyshores and @mayblin - thank you both sooo much.
Replies to "@mayblin @windyshores That is very interesting. Thank you for the link to that study. I do..."
@255anny, you are in a tough position!!! 2 separate sequences to think of. Evenity to a relay then a relay drug back to evenity. There might not be studies available with good number of subjects to show powerful statistical significance since evenity is relatively new. If it is just evenity--> prolia or reclast to be considered, then it'd be a lot easier. Obviously your endo has another round of evenity in mind for you after the relay drug. Hence not only you need to pick a relay drug that you are comfortable with, you need also think about which sequence (prolia -->evenity, or reclast --> evenity) will turn out better, on top of the worrying about potential prolia rebound effect. Toooo much! There are couple publications I read re evenity after 1-2 shots of prolia. It seems bmd increases were dampened but there were increase. There was a paper by Japanese researchers for evenity after reclast but results weren't clearly tabulated since there were other bps involved.
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Keith McCormick ("Great Bones") has apparently been saying that rebound is less severe with 1-3 Prolia shots. I have not heard this directly from him. You can ask your doctor.
I have been told twice that I am "my own protocol" or am a "pioneer" by two doctors. This concerned Evenity after Tymlos. I really don't like hearing that and can relate to your squeamishness about being one of the first to do something. But research has not caught up to what we need to know so I guess if our doctors approve, we have no choice but to try!
You are a monster researcher. I hope you stick around because you are very helpful!