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High anxiety regarding Reclast or Prolia decison for OP meds
Osteoporosis & Bone Health | Last Active: Sep 22 4:39pm | Replies (165)Comment receiving replies
Hi @255anny if I understood your sequence correctly: forteo-->evenity x1yr-->proposed prolia x 1year--> proposed evenity again, this article by Dr. McClung might be worth reading as a starting point:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260819/#jbm410512-bib-0014
Please look at Fig 1, part A for "phase 2 study and extension". Your sequence resembles line 5, which was evenity x2yr -->prolia x1yr --> evenity x1yr in that study. Total of 52 patients were involved in that particular arm. Then follow what the authors had referenced, #14, #17 and #18 articles will give you a total picture of what happened with bmds as well as btms for that sequence in the study. Happy reading and best luck!
Replies to "Hi @255anny if I understood your sequence correctly: forteo-->evenity x1yr-->proposed prolia x 1year--> proposed evenity again,..."
@mayblin
@windyshores
That is very interesting. Thank you for the link to that study. I do recognize 2 of the author's names 🙂 So, the treatment sequence my Dr is suggesting is not exactly new or unheard of. My concerns would be, 1). Would the second course of Evenity be enough to hold off the rebounding effect from the Prolia? 2) The very small number of participants in this study.
3) The fact that the increases in BMD were smaller than the initial increases that one gets from the first course of Evenity. 4). After the 2nd course of Evenity, would that be followed by Zolendronate?
I feel somewhat better about this sequence, but doing this kinda makes me feel like I'm doing my own drug study! I wish there was more written about this sequence. The safety aspect appeared ok in the study, so that might be of no high concern. My biggest concern is the rebounding from Prolia. But since the Prolia would be 1 year (2 doses) is the rebounding a risk after just 2 doses? I have read that it can happen after just one dose. Obviously, I have to make a decision. The lack of information about the sequence has me concerned. Of course, I could talk to my Dr but I'd like to be better informed before I do that, so that means I will dig further. Oh gosh, more sleepless nights.
@windyshores and @mayblin - thank you both sooo much.
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Thank you. As I have been digging thru so many studies, I’ve seen maybe 2 mentions of using an anabolic as a relay off of short term Prolia. But the studies usually end with “ further studies need to happen”. Thank you for sharing some more info. I will read.