@alvina, I bounce between 1500 to 3000 mgs of turmeric (1-2 pills) depending on how I’m feeling. And I concur with @janiceem regarding diet. I’ve switched to a heart healthy Mediterranean diet. Eliminating sugar, most dairy (an occasional cheat treat) white starch, and focusing on fish, chicken, vegetables and fruit have been significant in my opinion. Lots of great recipes that my wife has embraced and it’s turned into a fun lifestyle journey. I sleep better, I’ve lost weight, which has in turn led to more energy and a more consistent exercise schedule. Turning lemons (PMR) into lemonade. In hindsight, PMR may have added years to my life.