@normajean77 I totally concur with your opinion!

I am so sorry about your dreadful side effects. And it's not your fault as drs do not tell us enough information or they are ignorant. I am trying to decide what drug to take after coming off Prolia. They are all poisonous.

How do these drug companies get a licence? In America the drug companies pay 60% to the FDA. In the UK it's 80% subsidised by the companies. I am trying to find out what percentage they pay our Australian Licencing Authority.

Do look up Dr Aseem Molhotra. He has become an activist against these drug companies. Brave man!!

I had my first injection last Tuesday. Wound up in the emergency room at the hospital on Wednesday. My muscle spasms in my back and around my ribs was so severe. I had to go to the hospital. They put me on muscle relaxers which I’m taking. Now I noticed my wrist and my fingers on my right hand all swollen. Had to go to the emergency room to get my ring off of my ring finger. My joints hurt in my wrist and my fingers. I go to my endocrinologist tomorrow and I’ll bet he’ll say that’s not from the clap. I was perfect till I Took that infusion. Eight hours later I had chosen fever. Then all this pain started. I needed help getting out of the bed. I just hope this is a temporary reaction.

@normajean77 I had a reclassified infusion in August I had the infusion at 8:00 am and at 7:00 that same evening I didn’t feel the best so I layed down and within minutes I hurt so bad I had to get up got to the stairs and had to ride my moms chair lift down. My daughter had to call the ambulance because I couldn’t stand or walk. I was in the hospital for 3 days went for a follow up with my doctor and she didn’t know anything about the severe side effects. I called the doctor that prescribed the infusion and he had his nurse call me and question how severe my pain really was. I told her it felt like death and I would let my bones deteriorate before I ever had it again. I still have pain from it and it sucks!! When will it go away? When the drug is out of my system? Or is it just going to keep happening?

@normajean77 I got a Reclast infusion 11 months ago when I was 71, and had a VERY serious reaction. I will never do this again. I continue to have chronic side effects, the worst of which are recurring kidney pain, and serious joint, muscle, and bone pain. I also get recurring headaches, muscle cramps, vertigo, random whole body itching, etc. Like most everyone else, my PC doctor reacted with skepticism about it being caused by the Reclast, but since I was completely 100% healthy with NO issues when I got the infusion, and these symptoms hit like a ton of bricks 16 hours after the infusion, and have continued chronically ever since, I have zero doubts. I have looked, and I can find no real help for this. Studies have been done (posted on the Mayo Clinic site) showing the percentage of time these side effects occur, but I haven't found any answers for when they do. I was looking for how long it stays in your system, for how long this will continue to plague me. So far, here is the only answer I got, and it's not good:
"Reclast (zoledronic acid) stays in your system for a very long time because it binds to bone, with studies showing its effects and presence detectable in bone for many years, even up to a decade or more after treatment stops, though it's quickly cleared from the blood. While the drug's direct effects in the bloodstream are short-lived, its integration into bone means it can continue to work or be released slowly over years, influencing bone remodeling.
How it Works & Stays in Your Body
1. Rapid Blood Clearance: After an infusion, Reclast quickly leaves the bloodstream.
2. Binds to Bone: About half of the drug strongly attaches to bone mineral, effectively becoming part of the bone structure.
3. Long-Term Retention: Because it's incorporated into the bone matrix, it's protected from metabolism and can be released very slowly over many years.
Implications of Long Retention
• Extended Action:
This long retention means Reclast continues to slow down bone breakdown (osteoclast activity) for a long time, providing benefits long after the infusion.
• Drug Holidays:
Doctors may recommend "drug holidays" (stopping treatment) after several years (3-5 years) because the drug stays in the bones, allowing for a break while still getting benefits and reducing risks of serious side effects.
• Detectability:
Other bisphosphonates have been found in urine for years after treatment cessation, showing how long they can persist in the body.
In essence, while you don't feel the drug days after the infusion, its presence and action in your skeleton can last for years."

I am angry that I let my doctor talk me into the infusion, I am angry that I wasn't told or given a medical sheet that listed the potential issues prior to the infusion, I am angry that the drug company doesn't better inform the doctors, but I am mostly angry at myself --- I knew better than to let them put this serious drug in me, but in a moment of weakness, I caved and said okay -- something I will forever regret.