in reply to @lauramazhari Wow, that is a lot of diagnostic testing! I'm sorry, but can also relate to the undesired weight loss, as I have lost 31 pounds in the past 2 years, and trying to gain it back is useless. I take phenergan for the nausea, as the zofran causes headaches. While my hepatologist attributes some of the problems to using opiates for chronic pain, the problem can also be caused by an autoimmune disorder. Has this been discussed with you? I have the same symptoms as you have described, thus the upcoming endoscopy in a month or so. I wish I had something better to say to you, but just know that you are not alone. Easier said than done...best of luck