@bilchar2 the body tends to adjust over time and many of us who persisted out of necessity *severe osteoporosis and/or fractures) found that things improved.

However, some of us who cannot tolerate a full dose, went back to 1/4 dose for a week or two and then movde up slowly. This is the only way I could get on Tymlos and my doctor said he now suggests this in his practice.

The injection pen has "clicks" for dosing. Full dose is 8 clicks and 1/4 dose is two clicks. You can also play around with timing (I switched to morning). I have low blood pressure and Tymlos lowers it further so I drank water and ate salty things and had a blood pressure cuff. After awhile I stopped doing all that.

Main mesage: if you need it, do everything you can to make it work for you in consultation with your doctor. I went from severe to borderline osteoporosis in my spine!