@anne905, I experienced some immediate reactions to Tymlos beginning with my first injection, however, they weren’t as severe as the ones you describe; mine piled on and got increasingly worse over a two- to three-month period. By the third month, the adverse effects were, at times, excruciating. By the time I got my doc to believe these horrible, odd issues were caused by Tymlos, it had been 8-1/2 months. Almost immediately after stopping Tymlos, my symptoms disappeared.

I quickly began Evenity and had all twelve (24) injections without incident, save some injection-site pain and redness for a few days after several of the shots.

I should note that I tried oral meds previously and did not tolerate them at all. Since Tymlos, I’ve had GERD (although the “damage” may have been caused by the pain relievers I needed to try to deal with the adverse reactions to Tymlos).

My t-scores improved greatly, but because I was on both Tymlos and Evenity, without a DEXA between meds, I don’t know if the increases are due to one or both.

After Tymlos/Evenity, I chose Reclast as a maintenance drug - I’ve probably reached my lifetime limit but couldn’t convince myself that Prolia was the best choice for me going forward. Informed decisions!

What works for one of us may not work for another and this is an excellent forum to know what questions to ask and perhaps find some helpful information about OP and the issues surrounding it.

We are all on a journey and it helps to find others along the way whose maps and paths intersect with ours. Good health to you and all here!

Cheers!