@conyankee I’m not sure I have any advice other than letting the oncologist know about the side effects. When I first started taking Tag my oncologist told me to message them any time I had side effects. Initially, that was rash, fatigue, diarrhea., and nail issues. They prescribed me something for the rash. Other than that they told me to manage the symptoms with Imodium and aquafor for nails. I also take biotin everyday for nails. It help’s. I still have all of those symptoms but they are milder and less frequent.