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Pancreatic Cancer Recurrence after Whipple

Pancreatic Cancer | Last Active: Dec 17, 2024 | Replies (96)

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@mnewland99

Congrats to you that your chemo is working. I had surgery in late 2022 and was “cancer free” for 4 mo the before it metastasized it liver and abdominal area. I’ve been on GAC chemo for 8 months but now the chemo is no longer working. May I ask what your mutation cocktail is? Mine is ATM, KRAS12D, and TP53 and maybe more I’m not even aware of by now.

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Replies to "Congrats to you that your chemo is working. I had surgery in late 2022 and was..."

I'm sorry but I don't have the answer to your question. I am in the process of have blood maker testing done through Guardant. it's called the 360 test. This test will capture the DNA shed from tumors in the blood. It will provide a comprehensive overview of the genomics in both the primary tumor and metastatic sites. The test is used to detect gene mutations in circulating cell free DNA {cfDNA}. The hope is they will be able to identify the best form of treatments going forward. Hope this information may help. I certainly wish you all the best in your fight.

Let me update that post. Following a short chemo vacation (3 weeks) my CA19-9 numbers went up to over 536 after being in the normal range before chemo vacation. I also did have some growth in my lungs at this time but it turned out to be a benign nodule that was in response to difficulty breathing due to a slow gas leak we’ve had where we are living. I’m having a PET scan to recheck the “lesion” in the femur. The rising CA19-9 numbers could have been due to inflammation in my lungs since I had such difficulty breathing, but that’s my own guess. My CA19-9 numbers are once again in the normal range again and started to decrease once I resumed chemo after my chemo vacation back in late July. I also got some focused radiation (MRIdean) in October which might have also helped.