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Has anyone lowered their Abiraterone Dosage? To what effect?
Has anyone had personal experience (or know of others' experiences or know of related studies) taking half the usual dosage of abiraterone (i.e., taking 500mg daily instead of the usual 1000mg daily)?
If so, what was the effect on testosterone levels, and any other information you feel is relevant (except a recommendation not to do so, unless accompanied by pertinent experiences and/or studies, please)?
Thanks.
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I had persistent high PSA after RP. I started Eligard 3 months before SR. After SR, they put me on Orgovyx plus Abiraterone 1,000 mgs (5 mg prednisone). My insurance would only allow 15 day supplies for the first 90 days. I spent about half my time outside the country and it wasn’t practical to fly back every 15 days for refills. I did some research and found a study that concluded that the blood absorption of Abiraterone was basically equal when comparing 1,000 mgs taken after fasting versus 250 mgs taken with a high fat meal. I asked my MO about that and he said it was accurate and that they sometimes recommend the 250 mgs with a higher fat meal to people who either cannot easily afford the 1,000 mgs per day or for people experiencing difficulty SEs. As a point of reference, my PSA was 7 90 days post RP. My Gleason was 4+4. After 90 days of Eligard my PSA was 0.4. I was on Eligard for a total of 6 months and have now been on the Orgovyx plus 250 mgs Abiraterone for 2 months. My most recent PSA was 0.017 and most recent testosterone was 7.
Thanks for all the replies. I think continuing the thread may be of interest to some other men going forward.
My own situation has changed, however, I'm no longer on abiraterone: my liver tests were showing negative effects (I don't have access to the particulars right now to include in this posting), so I was taken off the abiraterone and prednisone.
Wow -- $18,000 to $20,000 per month for Abbie. I am afraid I would have told them where they could stick their Abbie!! I take 4 250 mg pills each morning the first thing I do when I get up for $36 per month and eat an hour or so later. The main issue is my energy level is very low, and I have a few hot flashes. I feel fortunate based on what I am reading -- wishing everyone on Abbie the best of luck.
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1 ReactionI'm not sure how much this costs. I get the prescription at no charge
If any of you have VA benefits see if your Oncoloigists will work w the VA.
In my case Mayo Phoenix works with the VA oncologist at NAVAHC
( Northern AZ VA). The scripts have a relatively small copay.
I did have my Abiraterone lowered to 750 ml.. I couldn't do crossword puzzles like before. I still have difficulty w mild cognitive loss (temporary?). Also a few boughts with severe nausea with vomiting, diarrhea, chills and disorientation. Two weeks left until 24 mos and then watch PSA. GOOD LUCK GUYS.