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Mixed results 1 year after Forteo: What are your thoughts?
Osteoporosis & Bone Health | Last Active: Aug 15 2:11pm | Replies (86)Comment receiving replies
@loriesco not to worry. Your P1NP numbers look good to me. Others will probably comment who have more experience with following the bone markers along with their meds but from my limited experience and studying this, yours are fine. The starting number of 49 is a mid-range number for how much bone building your body is doing without an anabolic med. The 90 reading is a good step up indicating your body is responding to the Tymlos by creating more bone.
OTH if your initial reading was 90 that might be a bit worrisome as an indication that your body without meds is trying to build a lot of bone and probably is also "cleaning up" a lot of bone. I do not know how taking Reclast might have effected your baseline P1NP but generally your numbers indicate bone building was normal range before and now it's kicked into high gear which is what you want.
You did not mention your CTX score which indicating bone breakdown is used along side the P1NP to get a view of the balance between building up and tearing down. If you have your CTX scores that might help clarify things further.
Replies to "@loriesco not to worry. Your P1NP numbers look good to me. Others will probably comment who..."
awfultruth, here's an old one. https://academic.oup.com/jbmr/article-abstract/24/9/1544/7599817?redirectedFrom=fulltext&login=false
here's another confusing article! here - correct me if I am incorrect it says that the P1NP numbers should be reduced, not increased! Ugh... I'm so confused! @awfultruth , @mayblin, @gently and @windyshores https://news.mayocliniclabs.com/2023/08/07/laboratory-testing-of-bone-turnover-markers/#:~:text=Bone%20turnover%20markers%20(BTM)&text=The%20most%20common%20bone%20resorption,measurable%20in%20urine%20and%20serum.
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thank you that is wonderful news. The CTX , along with the first P1NP of 49, was 322. Here's another mixed misunderstanding for me. Google says: "Beta-crosslaps test results are normal when less than 300 pg/ml. Above 300 pg/ml indicates increased bone resorption. In this case, the patient may have osteoporosis, Paget's disease, hyperthyroidism, and hyperparathyroidism."
So - do you understand why I am frustrated and anxious? My score is higher than 300, but that is supposed to be GOOD in the first part of the quote. Then, (like the P1NP) it goes on to say that it means negative stuff - osteoporosis and disease. Why can't people write in simple language. It should be qualified with "if you are on bone stimulating medications the response should be taken as an indicator that medicines are positively working in comparison to those who AREN'T taking them, which indicates an underlying concern.
Shouldn't I have had a second CTX at 3 months like the P1NP?!
The Reclast was done Aug. 2024. The Tymlos started mid March but I had such bad reactions I skipped the following month. The P1NP/CTX mid June and now the P1NP. Let me know if I should ask for a CTX to compare? thank you!!!