While I have not personally transitioned off of Prolia yet, I do have some insight. Dr. McCormick is a chiropractor that has done a lot of research and has helped a lot of people, however, he might not be up on the latest recommendations from the doctors that are running the studies on transitioning away from Prolia. At the 2024 World Congress of Osteoporosis, Dr. Bente Langdahl, who is a main author of many studies on this subject, strongly recommended starting Reclast immediately after Prolia treatment (6 months after the last Prolia shot). If you wait until it starts rising, it becomes more difficult to blunt the rise of CTX. Dr. Serge Ferrari, also presenting echoed the same advice. After the first Reclast infusion, then start watching CTX and re-dose with Reclast if CTX rises above baseline. You might end up taking three or even four infusions in the first year depending on your response. It has been shown that if you have a high CTX baseline and you are a long term Prolia user, you will have a more difficult time blunting the rise in CTX.