Good assessment of the Bredesen protocol:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7377549/
Excerpt:
“There are elements of the Bredesen protocol that could be beneficial and are largely free to patients. It is standard of care in dementia clinics to educate patients, without cost, on the lifestyle interventions for brain health that are supported to some extent in the scientific literature, including aerobic exercise, a Mediterranean diet, social and cognitive engagement, and management of cerebrovascular risk factors. Health insurance generally covers testing for reversible causes of cognitive change, such as thyroid disorders, vitamin B12 deficiency, or sleep apnoea. Some elements of the Bredesen protocol that have not been shown to be effective for brain health . . . a recent international consensus document concluded that “supplements have not been demonstrated to delay the onset of dementia, nor can they prevent, treat, or reverse Alzheimer’s disease or other neurological diseases that cause dementia”.