Oh yea they are used in my experience as first option biologics. I was on enbrel and methotrexate but the methotrexate was making my liver enzymes spike and by the time we lowered it enough to stop that, it was too low to prevent developing antibodies to enbrel. So i had to switch to humira. And was on that a few years until it just quit being effective. Now I'm on Remicade.

Personally i save prednisone for flares. You just cant stay on it and it causes osteoperosis in a lot
Of people. So its my last
Resort drug in flares - its awesome but dangerous in that if you stay on it, your body decides it doesn't need to produce its own cortisol any longer since Prednisone is supplanting your own production. Then you can be in a hot mess trying to wean off prednisone.

Way more than you want to know. But there isnt a drug ir. Combo of drugs someone here hasnt been on for RA. So ask away 🙂