Has anyone lowered their Abiraterone Dosage? To what effect?

I had persistent high PSA after RP. I started Eligard 3 months before SR. After SR, they put me on Orgovyx plus Abiraterone 1,000 mgs (5 mg prednisone). My insurance would only allow 15 day supplies for the first 90 days. I spent about half my time outside the country and it wasn’t practical to fly back every 15 days for refills. I did some research and found a study that concluded that the blood absorption of Abiraterone was basically equal when comparing 1,000 mgs taken after fasting versus 250 mgs taken with a high fat meal. I asked my MO about that and he said it was accurate and that they sometimes recommend the 250 mgs with a higher fat meal to people who either cannot easily afford the 1,000 mgs per day or for people experiencing difficulty SEs. As a point of reference, my PSA was 7 90 days post RP. My Gleason was 4+4. After 90 days of Eligard my PSA was 0.4. I was on Eligard for a total of 6 months and have now been on the Orgovyx plus 250 mgs Abiraterone for 2 months. My most recent PSA was 0.017 and most recent testosterone was 7.

Thanks for all the replies. I think continuing the thread may be of interest to some other men going forward.

My own situation has changed, however, I'm no longer on abiraterone: my liver tests were showing negative effects (I don't have access to the particulars right now to include in this posting), so I was taken off the abiraterone and prednisone.

Wow -- $18,000 to $20,000 per month for Abbie. I am afraid I would have told them where they could stick their Abbie!! I take 4 250 mg pills each morning the first thing I do when I get up for $36 per month and eat an hour or so later. The main issue is my energy level is very low, and I have a few hot flashes. I feel fortunate based on what I am reading -- wishing everyone on Abbie the best of luck.

I'm not sure how much this costs. I get the prescription at no charge

If any of you have VA benefits see if your Oncoloigists will work w the VA.
In my case Mayo Phoenix works with the VA oncologist at NAVAHC
( Northern AZ VA). The scripts have a relatively small copay.
I did have my Abiraterone lowered to 750 ml.. I couldn't do crossword puzzles like before. I still have difficulty w mild cognitive loss (temporary?). Also a few boughts with severe nausea with vomiting, diarrhea, chills and disorientation. Two weeks left until 24 mos and then watch PSA. GOOD LUCK GUYS.