For 20 yrs Ive had APS, 13 DVTS. Ive been on Warfarin, with inr at3.25 (Dr wants me at 3) Ive also been on Fondaparinux 7.5mg injections. I ve broke through both with DVTs. It seems that blood Thiners are not working, none of my Drs have known anyone with this problem. I was referred to Mayo Clinc BUT 'they do not have a thrombose clinic anymore'. So, now have been referred to a specialist in Orlando. One of my Drs said 'Im sitting on a time bomb'. Has anyone one else had this problem or has heard of this? Now, Im taking Xeralto. which is contraindicated for APS. Im also taking 2 aspirin a day on my own.