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Methotrexate and Hydroxychloroquine

Autoimmune Diseases | Last Active: Oct 14 7:42pm | Replies (80)

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@slkanowitz

Just FYI, MTX is stronger than hydroxychloroquine and often used together for many inflammatory autoimmune disorders. The eye side effects of HCQ are rare and usually reversible if changes are seen on your eye exams and drug is stopped. The drugs often require tweaking of doses depending on your response and any side effects. Anyone on MTX should be on daily folic acid supplement. HCQ can also rarely cause neuromuscular toxicity, so report any muscle weakness to your doctor and ask to have muscle enzymes checked (CK, aldolase, AST, ALT). I experienced this side effect and it took a decade and muscle biopsy at Mayo Clinic to figure out why I couldn’t walk and had severe muscle atrophy. It is rare so don’t be afraid of taking HCQ, just check it out if you develop any muscle weakness so it is caught early. I hope you all feel as well as possible and tolerate the meds that help control your diseases! Keep on trudging 😀

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Replies to "Just FYI, MTX is stronger than hydroxychloroquine and often used together for many inflammatory autoimmune disorders...."

Thank you, that’s very helpful!