Any pre-injection tips for Tymlos?

I will be starting Tymlos later this week, and am seeking any suggestions, tips, tricks that anyone would care to share. I am, of course, nervous! So far I think I have read: hydrate well before and eat something a bit salty, watch D3, consider taking it at night so as to sleep through side effects, take at a time I can lay down if necessary after, and the wonderful windy shores method of stepping up the dose if I can’t tolerate the full dose! Oh! And ultra fine needles if the ones I receive initially don’t suite….Anything else? Thanks!

I will be starting Tymlos later this week, and am seeking any suggestions, tips, tricks that anyone would care to share. I am, of course, nervous! So far I think I have read: hydrate well before and eat something a bit salty, watch D3, consider taking it at night so as to sleep through side effects, take at a time I can lay down if necessary after, and the wonderful windy shores method of stepping up the dose if I can’t tolerate the full dose! Oh! And ultra fine needles if the ones I receive initially don’t suite….Anything else? Thanks!

@babbsjoy Tymlos has proven, at least for me to be the key to growing bone over the past 2 years. In total I had a 14% gain in my spine…about 1% in my hip. I wish I could have stayed on it longer, but it appears after about 18 months, the gains are pretty minimal and it had only been approved for year period.
I had very few side effects, mainly in the beginning but switching from morning to bedtime injections helped a lot. Throughout the 2 years I would have periodic bouts of ankle discomfort and noticed my tummy pooching a bit more than normal. The ankle pain stopped once I finished my 2-years.
Now I’m deciding what’s next. I’m guessing it’s going to be Evenity. I’m holding off a bit but don’t want to wait too long.
I did all 8 clicks with my injection pen from the beginning but many woman start with a lower dose and build up. I’m really happy I went the Tymlos way.

Hello @babbsjoy,

This is a great question and discussion to help yourself and others share tips on how to get prepared for starting a new medication or facing a procedure. I combined your discussion and the replies with an existing discussion on the same topic titled, "Any pre-injection tips for Tymlos?" - https://connect.mayoclinic.org/discussion/any-pre-injection-tips-for-tymlos/ so that everyone who has shared their experiences could meet in the same place.

@babbysjoy, if you are comfortable, what in particular has you the most nervous? Have some of the suggestions helped ease some of your nerves?

@babbsjoy Tymlos has proven, at least for me to be the key to growing bone over the past 2 years. In total I had a 14% gain in my spine…about 1% in my hip. I wish I could have stayed on it longer, but it appears after about 18 months, the gains are pretty minimal and it had only been approved for year period.
I had very few side effects, mainly in the beginning but switching from morning to bedtime injections helped a lot. Throughout the 2 years I would have periodic bouts of ankle discomfort and noticed my tummy pooching a bit more than normal. The ankle pain stopped once I finished my 2-years.
Now I’m deciding what’s next. I’m guessing it’s going to be Evenity. I’m holding off a bit but don’t want to wait too long.
I did all 8 clicks with my injection pen from the beginning but many woman start with a lower dose and build up. I’m really happy I went the Tymlos way.

@dooshie
Congrats on your great results from Tymlos! And I wish you every blessing with whatever you choose next….

I am very encouraged to hear about your Tymlos experience . It makes me feel much better! Thank you so much for taking the time to share.

To everyone that has joined this thread I began in May - Thank you all so much!
I am about to finish my third month so I do not have any P1NP data to share yet but I wanted to say it is great to have this incredible community. I do not have any pre-injection advice and I am one of the very lucky ones that has no side effects from TYMLOS. Nothing. Ever the worrier, I called the company nurse line and asked if this was a sign the medicine wasn't working. She said there was no data to support this correlation, but there are a percentage of people who have no benefit from the medicine. I hadn't really processed that when I started but it makes sense. There is no panacea for any condition. Has anyone out there not had benefit from TYMLOS? I am just hoping for 10% improvement in spine to get me out of OP range. I guess I will learn more soon enough. One thing I will pass on is to be sure to have your Vitamin D level checked often. The ideal range is 30-50. Mine was 50 in May, so I stopped the 2000 IU daily supplement and retested in August and it had dropped to 29. I learned I am someone despite summer sun, will always need a supplement. I will now get D checked every 3 months to be sure I keep optimal levels. **It's important to know your body and what you need and then advocate for that to your medical team** I will share P1NP (August) and DEXA (September). Wishing everyone good health!

@esb13 hope to hear Tymlos is working well for you.

Just wanted to mention that I once read that Tymlos "eats D3." My level was 52 before starting. I actually went up to 3,000 units/day during Tymlos and my level stayed essentially the same . I basically tripled my intake.

When I stopped Tymlos, that level of D3 was causing my level to rise so I went back down.

Main message: I learned that I needed more D3 while on Tymlos!

@esb13 hope to hear Tymlos is working well for you.

Just wanted to mention that I once read that Tymlos "eats D3." My level was 52 before starting. I actually went up to 3,000 units/day during Tymlos and my level stayed essentially the same . I basically tripled my intake.

When I stopped Tymlos, that level of D3 was causing my level to rise so I went back down.

Main message: I learned that I needed more D3 while on Tymlos!