@guinevere Great question and I believe some people are doing that. My doctors don't use Prolia unless absolutely necessary and hesitate for me due to my lupus.

But some on here, and McCormick, are saying that with 1-3 shots, the rebound can be handled well with a bisphosphonate. Prolia does bring increases in bone density but rebound can reverse those if not followed up with Reclast (or alendronate ( if only 1-3 Prolia shots according to McCormick and others).

I have a friend in her mid-80's who is taking Prolia for life so depending on age, that is an option that makes stopping with rebound unlikely.

I did Evenity after Tymlos but only 4 months, then Reclast. I am apparently the only patient in both my endos' offices doing that but others on this forum and someone in a masterclass I attended with Lani Simpson were doing that sequence.,

We need so much research and years of experience with these drugs, the various combinations and sequences. My choices are mainly guided by what I can tolerate!