Wellbutrin/Buproprion affects the dopamine receptors and is very effective at helping move people from the state of malaise that is a symptom of the underlying trauma that they incorrectly call depression.

SSRIs like Zoloft do not work; they are just about the same as a placebo, and the difference is not clinically significant. What SSRIs and SNRIs do is retard cognition and blunt emotions (really the same thing); this can feel like a relief from the depressive symptoms and frankly can be a welcome break from the suffering.

Unfortunately retarding cognition takes away the most critical resources needed to recover from whatever the underlying trauma is, thinking and feeling.

Pharmaceutical companies have known this for a very long time. All we are is profit centers to them.

I hope you live in peace and good health.