Hi @slakhani, this doesn't sound easy. My Crohn's doctor and Dr. Addrizzo-Harris, who is my bronchiectasis & MAC doctor and is one of the prominent experts, both want me to stay on the Humira because it has kept the Crohn's almost entirely in remission for 7 years. Dr. Addrizzo says being on an immune modulator or suppressant is an indication FOR the antibiotic treatment since you are higher risk for more rapid MAC progression or even disseminated MAC, which is when it spreads to other organs and can be even more serious. Have you and your father discussed the bronchiectasis / MAC treatment options with his pulmonologist and with his rheumatologist? Can you get them to consult each other? (My 2 doctors share other patients in the same situation and work together on these cases.)
I am going to start antibiotics in coming weeks. Right now I'm in the screening phase for a trial that includes either inhaled Amikacin or placebo, + oral azithromycin + oral erythromycin 3 times a week for a year. If for some reason I don't qualify for the study, I will still be treated with antibiotics. I'm boning up here on the probiotics that can best help so the antibiotics don't in turn mess with the Crohn's.
You can read here about the "Big 3" which are standard antibiotic treatment for MAC, if you aren't familiar. People here have varying experiences with being on 3 antibiotics for a year, but it sounds like exploring your father's treatment options is very important if that hasn't been done yet.
All best wishes, share what happens.