I’ve had the same experience as retireddoc. Two years on Lupron/Eligard (3 month shots) along with Zytiga (Abiraterone) and Prednisone. My last shot was early April and I thought by July I’d be feeling good. Just the opposite I’ve been sore, fatigued, muscle and joint aches, weakness in hands and feet. My family doc thought it was prednisone withdrawal and put me on a very gradual tapering regimen starting back at 10mg daily. That resolved the problems until I got down to 3mg and all the aches and pains returned This is miserable but I guess I’ve got to tough it out until my body starts making testosterone and cortisol