I started on Eberolimus 10mg daily March 2023. I developed mouth sores which bece more manageable with Dexamethasone liquid “swish and spit”. Over the 10 months I took 10mg, diarrhea was a constant, I developed hypertension, high cholesterol, and Type II diabetes, lost 50 pounds and by January 2024, I felt awful. There was a reluctance by my local oncologist to lower or stop the dosage as a CT seemed to indicate a new liver mass present. After consulting with my Mayo oncologist at Rochester, including an overread of the CT scan, He determined I had a “culmination of toxicities”, and I went off Everolimus for 2 weeks, then restarted at 5Mg dose on 2/15/24. Since then I have regained 16 pounds, feel better overall with better energy levels and my diabetes and high cholesterol have disappeared thankfully. I will return to Mayo mid September for scans and follow up to make sure the lower dose is effective. Diarrhea remains and I continue on Lanreotide injections every 28 days which I have been on since November 2018. Crossing my fingers for OK reports at my September appointments.