Hey lapruzzese:

I first started with Wellbutrin and after some relatively high PHQ-9 scores (7-9 if I remember right), the consulting psychiatrist recommended I take a low dose of Sertraline. So, my experience is backwards to yours. At first, I did not notice anything, but I eventually it took me over the edge emotionally.

After a few weeks, I was emotionally all over the place. I had thoughts of self-harm. I had real emotional highs. I was losing my inhibitions. I did not really notice this for a few weeks. Once I did, I told my doctor I was getting off this. Months later, I was in the group therapy session and one of the other members of the group said I was experiencing mania...not I know how that feels.

Anyway, that was my experience. I do not want to scare you, but my advice would be to watch your emotions if you start both meds. In your case, it might help. If anything like what I experience starts, then contact your doctor right away. I kept with Wellbutrin (a psychiatrist friend of mine recommended it) and have had no issues.