I have been since 11/2023 and found it to be truly life changing! Just within the last few months I have found it to be less effective.....don't know if that means I am advancing my disease or whether I am having an exacerbation and just need a course of prednisone taper. I also started a new medication about the time I started Dupixent and it may be interfering in some way. I don't think I would have made it this far without the Dupixent in conjunction of having zephyr valve placement. What a world of difference. Thank you for your response!