I would not do Prolia...my endocrine dr had said once you start it, if you stop, your bone loss will be worse. I don't like any drugs that will set you back worse than you started and cause dependence. Due to connective tissue disorder I have osteoporosis already in early 50s, and the thought of being on some bone drug the rest of my life is depressing and daunting. It seems like whatever you take, then you have to keep taking something forever. I wonder if that is true. I've tried so many osteoporosis drugs and failed. My body is so sensitive to drugs, and I think they need more dosing options for women. We are not all the same body size, not the same. They need to consider the effects of being on hormone replacement also in conjunction with these drugs...I doubt this is studied. All that being said, hoping one day soon there is a bone building drug like forteo i might be able to tolerate. Every time i try an anti resorptive like fosamax or similar I get horrible body pains, jaw pain, teeth pain. I got awful headaches on tymlos, and insomnia/jaw pain trying Evenity.