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CTX Marker

Osteoporosis & Bone Health | Last Active: Oct 6 11:06am | Replies (77)

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@gently

@rajmayo22, hi.
From your numbers I would guess that you are having good response to Tymlos. If you are completing a second year, depending on your dxa results, you might want to ask your provider about taking Tymlos for a third year.
Bone markers are in the toss currently. Protocolled use of bone markers is for determining whether a medication is effective. That would require before medication use testing, and, usually, during medication use testing. It is becoming less fringe to use one set of markers in comparison with each other. This video at 9 minutes and 22 seconds, from an impressive (but very expensive) md, outlines a math method for determining the ratio between P1NP which measures a bone fragment indicating bone acquisition against a CTX protein fragment indicating bone loss.


These bone markers (especially CTX) fluctuate during the day, after eating, with exercise, with the use of biotin and collagen.
With the use of PTH therapies P1NP is said to rise faster than CTX, until the osteoblasts stimulate a rise in osteoclasts and the CTX catches up.

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Replies to "@rajmayo22, hi. From your numbers I would guess that you are having good response to Tymlos...."

Thank you so much for your feedback.

My CTX and P1np #s were after overnight fasting and no Ca and VitD 72 hours prior to drawing of blood. I stopped taking Biotin before beginning Tymlos two years ago and never taken supplemental collagen.

I am mostly vegetarian with reliance on lentils, some greens and veggies, nuts and fruits, and dairy and occasional eggs and chicken as protein source. (Excuse me for my sharing of diet info. here.)

I will watch the video before my Endo appt. and contact Radius Labs to see if they any guidance on 3rd year of treatment.