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Bone turnover markers (CTX and P1NP): do you have a baseline?

Osteoporosis & Bone Health | Last Active: 2 days ago | Replies (197)
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@rajmayo22

With your interpretation seems like CTX of 321 is normal. Don't know if that's good or bad after Tymlos.

CTX and P1NP were done after 23 mo of Tymlos. Have an appt w/Endo next week. Considering Fosamax which I had taken soon after menopause for 10 years or so. DEXA in Oct.

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Replies to "With your interpretation seems like CTX of 321 is normal. Don't know if that's good or..."
mayblin | @mayblin | Aug 4, 2024

The CTX graph was a distribution pattern among untreated postmenopausal women with osteoporosis. Once a person starts an anabolic such as Tymlos or Forteo, both bone markers P1NP and CTX start dynamic changes. During the last few months of Tymlos treatment, both markers trend toward baseline. Publications indicated there are strong correlations between early changes (3-6 months) of bone markers and the subsequent bmd increase.

It's interesting that you had taken fosamax for 10 years in the past. Did you have a drug holiday before you started Tymlos?

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